Panels in Therapy. VII. Management of an Incompatible Hemolytic Transfusion Reaction

Immunosuppressive therapy in Rh-incompatible transfusion.

Postpartum injections of 250 ,tg of anti-D gammaglobulin prevent Rh-immunization of Rh-negative women, with an im-munosuppression success rate of approximately 95% (Eklund and Nevanlinna, 1971). The average fetomaternal transfusion, however, is less than 1-5 ml in 98% of cases (Clarke et al., 1966), and so far there are few observations on trying to suppress primary Rh-immunization due to massi...

Hemolytic transfusion reaction due to anti-IH.

BACKGROUND Anti-IH is usually a clinically insignificant antibody that may complicate a serologic workup. However, it can occasionally cause hemolysis. We report a rare case of acute hemolysis caused by anti-IH. CASE REPORT A 60-year-old man with a long history of chronic myelomonocytic leukemia and anemia, blood group A, D+ was found to have an unidentified antibody on serologic workup. He r...

Hemolytic transfusion reaction due to anti-A.

Transient thrombocytopenia after incompatible red blood transfusion in an infant girl with autoimmune hemolytic anemia.

We report on 5-month-old girl with severe autoimmune hemolytic anemia (hemoglobin 2.9 g/dl, positive direct Coombs test) in whom thrombocytopenia developed after red blood cell transfusion. The platelet count was 62.1 x 10(4)/mm3 on admission and rapidly fell to 6.0 x 10(4)/mm3 rapidly after transfusion of incompatible red blood cells with intravenous predonisolone administration. No increased ...

Transfusion therapy in autoimmune hemolytic anemia.

Autoimmune hemolytic anemias include warm and cold reactive autoimmune hemolytic anemias (WAIHA and CAD), paroxysmal cold hemoglobinuria (PCH), and drug-induced hemolytic anemias. If autoimmune hemolytic anemia is suspected, the clinical history should be communicated to the transfusion service, because specific tests to confirm these diagnoses are not routinely performed. This includes evaluat...